Senior Director / Clinical Lead (Study Physician) Cardio
Description
Our client is a well-funded, clinical-stage biotechnology company focused on developing innovative therapies for serious cardiovascular diseases with significant unmet medical needs. The organization is advancing novel therapeutic approaches designed to improve outcomes for high-risk patient populations through cutting-edge science and rigorous clinical development.
The company combines deep scientific expertise with an entrepreneurial biotech culture where individuals have the opportunity to make a meaningful impact across clinical strategy, development, and execution.
POSITION OVERVIEW:
Our client is seeking an experienced and highly motivated Senior Director / Clinical Lead (Study Physician) to provide clinical leadership for ongoing and planned cardiovascular clinical development programs.
This individual will play a critical role in the design, execution, monitoring, and interpretation of clinical trials, with immediate focus on a later-stage cardiovascular program. The successful candidate will serve as a key medical and scientific leader across cross-functional study teams and will work closely with Clinical Operations, Biostatistics, Regulatory, Safety, Translational Medicine, and external investigators.
This role is ideal for a hands-on clinical development professional who thrives in a fast-paced biotech environment and enjoys operating at the intersection of strategy, execution, and scientific innovation.
Location
Princeton, New Jersey area
Features
WHAT MAKES THIS OPPORTUNITY UNIQUE:
- Opportunity to help lead development in an underserved and highly impactful cardiovascular disease setting
- Opportunity to work on a novel therapeutic platform with significant scientific and clinical potential
- Direct influence on clinical strategy and study execution within a growing biotechnology company
- Highly collaborative culture with experienced leadership and development teams
- Opportunity to contribute meaningfully to programs designed to improve outcomes for severely ill cardiovascular patients
Responsibilities
- Serve as the clinical lead and study physician for ongoing and planned cardiovascular clinical trials
- Provide medical oversight and leadership for study conduct, patient eligibility review, protocol deviations, safety monitoring, and data review
- Lead development and review of clinical protocols, protocol amendments, investigator brochures, clinical study reports, and related study documents
- Partner cross-functionally with Clinical Operations, Biostatistics, Data Management, Regulatory Affairs, Pharmacovigilance, and Translational teams to drive successful study execution
- Monitor aggregate safety and efficacy data and contribute to ongoing interpretation of clinical findings
- Collaborate with investigators and study sites to support enrollment, protocol adherence, and high-quality study conduct
- Participate in dose selection discussions, endpoint strategy, and broader clinical development planning
- Contribute to regulatory submissions and interactions, including briefing materials and responses to health authority questions
- Support publication strategy, scientific presentations, and external expert engagement
- Drive cross-functional alignment and facilitate efficient decision-making within study teams
- Maintain deep understanding of the competitive landscape and evolving cardiovascular clinical development trends
Qualifications / Requirements
REQUIRED:
- MD or PharmD required
- Minimum 5+ years of sponsor-side clinical development experience within biotech or pharmaceutical industry
- Prior experience serving as a Clinical Lead, Study Physician, Medical Monitor, or similar clinical development role
- Experience supporting Phase 1–3 clinical trials
- Strong clinical judgment and ability to apply scientific knowledge to real-world study execution challenges
- Experience interpreting clinical and safety data
- Demonstrated ability to work cross-functionally within matrixed development organizations
- Excellent written and verbal communication skills
- Ability to operate effectively in a fast-moving biotech environment
PREFERRED:
- Cardiovascular clinical development experience strongly preferred
- Experience in hypertension, heart failure, cardiometabolic disease, renal disease, or vascular medicine highly desirable
- Experience interacting with investigators and clinical trial sites
- Experience with INDs, regulatory submissions, and FDA interactions
- Prior experience in small or mid-sized biotech companies
- Experience with novel therapeutic modalities including oligonucleotide or genetic medicine platforms is a plus
IDEAL CANDIDATE PROFILE:
The ideal candidate is:
- scientifically rigorous,
- operationally strong,
- decisive,
- collaborative,
- and comfortable working hands-on within clinical trial execution.
This is a highly visible role for someone who enjoys being close to the science, the data, and the day-to-day realities of running impactful clinical studies.
EMPLOYMENT TYPE:
Our client is open to considering:
- Full-time permanent candidates
- Contract-to-hire candidates
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