Next Generation Sequencing Specialist
Description
Our client is a successful global biopharmaceutical and diagnostics company focused on developing novel technologies and applications for single-cell analysis to advance precision medicine for various types of cancer, and continuing to expand its unique capabilities and presence across the globe.
They are seeking to hire an NGS Specialist within its R&D group who has strong skill sets in hands-on next generation sequencing, library preparation, new assay development/design, and clinical lab/benchwork experience (R&D mindset). This is an attractive opportunity for someone who has a passion for hands-on experimentation in research-intensive settings, experience with assay development and NGS wet-lab techniques looking to join a forward-thinking company focused on developing diagnostics and personalized therapies that can significantly impact cancer patient care and treatment outcomes.
Location
This position is based in the Philadelphia/Huntington Valley, PA area.
Features
- Successful & Fast-Growing Company: With a long heritage and track record in the healthcare industry and a pioneer of liquid biopsy and single-cell technology, our client is focused on becoming the global leader in non-invasive cell-based applications for easier, faster and more precise diagnostic and therapeutic approaches.
- Impactful Work: This is an excellent opportunity to join a dynamic R&D team focused on understanding cancer progression and developing diagnostic tools that can significantly impact patient care/treatment options going forward.
- Cutting-Edge Technology: You will be joining at an exciting time, as the company is growing and continues to invest in the present and future for the improvement of patient health by leveraging world-class technology to identify cancer drivers and develop marker panels for various disease stages.
- Great Work Culture: Our client really prides itself on maintaining an excellent work culture that is positive, collaborative, supportive, caring, and diverse.
- Potential Growth Opportunities: The company's continuing growth will lend itself to personal growth opportunities within the team and potential for career advancement (without requiring a PhD).
Responsibilities
The NGS Specialist will play a key role in wet-lab bench work, designing, executing, and validating molecular/genomic tests within a design control framework and contribute to the development of cutting-edge molecular assays. This role will focus on characterizing intra- and inter-patient heterogeneity in circulating tumor cells (CTCs) in various cancers, utilizing single-cell barcoding and other advanced techniques. This team is dedicated to generating multi-omics maps of rare single cells and characterizing ctDNA/ctRNA profiles from plasma to understand the natural history of cancer progression.
- Utilize your experience in NGS wet-lab techniques, dedicated to creating and validating innovative solutions for unmet research and clinical needs.
- Develop high-sensitivity molecular assays for NGS and digital PCR from enriched rare blood cells and human plasma.
- Hands-on involvement in the design, development, qualification, and validation of molecular-based assays, supporting pre-clinical trials.
- Execute various RNA/DNA sequencing workflows, including sample preparation, library construction, data generation, data processing, and interpretation of results.
- Utilize different molecular biology technologies, including RNA and DNA isolation, PCR, quantitative real-time PCR, digital PCR, and sequencing of small numbers of cells to single cells.
- Support ongoing development, validation, and troubleshooting of assays for low cell number input assays, including targeted RNA-seq, WES, and WGS at the single-cell level.
Qualifications / Requirements
- Bachelor's or Master's degree in Molecular Biology, Biochemistry, Genetics, or a related field.
- Pharma/Biotech industry or academic experience in cancer genomics, tumor biology, biochemistry, molecular biology, or related fields, with at least a few years of hands-on laboratory/benchwork and new molecular-based assay development experience.
- Extensive experience in NGS technologies and applications (RNA-Seq, WES, WGS).
- Proficiency in molecular biology techniques, including RNA/DNA isolation, PCR, quantitative real-time PCR, digital PCR, and sequencing of small numbers of cells to single cells.
- Experience in developing molecular-based assays/diagnostic assays within a design control environment.
- Knowledge of clinical biomarker discovery, development, and analysis, assay development/validation, and relevant platforms.
- Working knowledge of cell-based and molecular models used in cancer biology is a plus.
- Experience working with clinically relevant patient sample types (e.g., whole blood, plasma).
Cornerstone's Privacy Policy
Cornerstone Search Group considers all inquiries, resume submissions, and any other personal information submitted to us as confidential information. This information will not be shared with any parties outside of Cornerstone Search Group without your prior permission.